Endocrine Abstracts

Introduction: Breast cancer is the second most common neoplasm in women. Hormonal replacement therapy and combined hormonal contraception are established extrinsic hormonal risk factors for breast cancer. Therefore, the increase in the prevalence of infertility and the use of assisted conception techniques have raised questions regarding the potential risk of hormone-dependent neoplasms. We report the case of a woman diagnosed with bilateral metastasized breast cancer soon aft...

Introduction: Functional islet β-cell tumours represent 1–2% of all pancreatic neoplasms. Diagnosing this type of tumour is often challenging because they present with unspecific clinical features overlapping more common syndromes. Diagnosis involves expensive testing, so, establishing whipple’s triad and excluding causes of exogenous hyperinsulinaemia is crucial before initiating investigation.Objective: To report a rare case of a proinsu...

Introduction: Proinsulinoma is an infrequent subtype of pancreatic neuroendocrine tumor (pNET), characterized by the excessive secretion of proinsulin, leading to pronounced hypoglycemia. Clinical manifestations comprise neuroglycopenic and autonomic symptoms, including cognitive impairment, seizures, visual disturbances, diaphoresis, tremors, syncope or coma. Diagnostic modalities involve blood assays and imaging to detect heightened proinsulin production and determine the tu...

Introduction: Pituitary tumours are considered benign, however some exhibit an aggressive behavior. Defining a timely treatment is challenging due to absence of accurate prognostic predictors.Objective: To evaluate radiological and histopathological features of aggressive pituitary tumours.Methods: Multicenter and retrospective study. Criteria for aggressiveness were: invasion to sphenoid and/or cavernous sinus; growth progression ...